The Museo dell'Opera di Santa Croce is located in the famous Church of Santa Croce , a masterpiece of Florentine medieval architecture.

The Museo dell'Opera di Santa Croce includes the entire complex of Santa Croce : the Basilica, the Pazzi Chapel and the Cloisters . The church was built at the end of the thirteenth century on a project by Arnolfo di Cambio . Among the works preserved inside are the " Crucifix" and "The Annunciation Cavalcanti" by Donatell o. The Basilica is the burial place of the most important artists and writers of Italian history: Galileo Galilei, Leon Battista Alberti, Vittorio Alfieri, Ugo Foscolo and Michelangelo are some of the personalities buried in the church.

The Museo dell'Opera di Santa Croce was established in 1959 and houses masterpieces of Florentine art. Some of the masterpieces present are the " Crucifix" by Cimabue, symbol of the destruction caused by the 1966 flood and the Della Robbia terracotta collection. Symbol of the architecture of the complex is the Pazzi Chapel built by Brunelleschi with decorations by Desiderio da Settignano and Luca and Andrea della Robbia. Adjacent to the Pazzi Chapel is the splendid fourteenth- century cloister of the convent.